This study aimed to evaluate and compare the remineralizing efficacy of four contemporary biomimetic agents—Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP), Functionalized Tricalcium Phosphate (f-TCP), Nano-Hydroxyapatite (n-HAp), and Nano-Bioactive Glass (n-BAG)—against a standard sodium fluoride (NaF) control and a negative control using a standardized pH-cycling model on primary tooth enamel. One hundred fifty enamel slabs were prepared from non-carious human primary molars. After baseline assessments of surface microhardness (Vickers Hardness Number, VHN) and elemental composition (Ca/P ratio via EDX), artificial caries-like lesions were created. Samples were randomly allocated into six groups (n=25) for a 21-day pH-cycling regimen. Treatment groups received daily applications of their respective agent, while the negative control received deionized water. Post-treatment, microhardness, EDX, and scanning electron microscopy (SEM) were repeated. Demineralization significantly reduced microhardness and Ca/P ratios in all groups (p0.05), indicating near-complete recovery. CPP-ACP was significantly more effective than f-TCP (p CPP-ACP > f-TCP > NaF.
A Thu, study studied this question.