Supplementary Figure S2 from Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.

Chromatin state of different gain region. The regions of gain tend to fall within active chromatin regions with G3, G4, G5, G6, and G8 lying exclusively within A-compartments (100%) across B-cell differentiation states and MM cell lines (U266, RPMI8226, and KMS11). The G1 region also followed this pattern with the exception of KMS11 (where A-compartment represented only 78% of the region). The G2 region showed variability between the normal and malignant phenotype, with moderate switching from to B-compartments of 24%, 21%, and 37% in U266, RPMI8226, and KMS11 respectively. The compartment profile of the G7 region is interesting as each sample contained considerable B-compartment percentage (range 16-82%) but within the conserved A-compartment across all samples lies the well characterised oncogene ABL2. The G9 region showed the greatest variability across all samples and was shifted more towards inactive chromatin (range 45-97%). NBC=Naïve B-cell, MBC=Memory B-cell, GCBC=Germinal Center B-cell, PC=plasma cell.