Supplementary Figure 3 from Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells

Key Points

• CAR T-cell infiltration occurs alongside mouse retina expression of GPC2 and GD2, characterizing target tumor engagement within the intraocular model.
• Assessment of the intraocular model tracks systemic toxicities alongside antigen loss, defining critical safety and resistance endpoints in treated mice.
• Mouse model evaluation indicates localized CAR T-cell dynamics and systemic toxicity; mouse model, further preclinical investigation is required.