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Intervertebral disc degeneration is a leading cause of disability. In this study, quantitative T2 and ultrashort echo time magnetization transfer ratio (UTE-MTR) measurement techniques are utilized to assess biochemical component changes for better understanding of the mechanism of disc degeneration using a rabbit spinal intervertebral disc degeneration model. Both T2 and UTE-MTR values of nucleus pulposus (NP) are significantly different between normal and degenerated discs, indicating water and/or proteoglycan content changes.
Athertya et al. (Wed,) studied this question.