Synthetic high-b-value reduced field-of-view DWIs in breast cancer elevates lesion clarity and CNR

Our study showed synthetic DW images (syDWIs) with high b-value provided better lesion conspicuity, image quality and contrast to noise (CNR), reduce scan time of DWI acquisitions especially at very high b-value, and improved lesion visualization particularly in dense breast. Moreover, derived ADC values showed good consistency between scanned and synthetic DWIs. Therefore, syDWIs with b value of 800 s/mm2 have great potential in elevation of diagnosis confidence and efficacy on tumors and high repeatability of ADC values is helpful in replacement of scanned high-b-value DWIs in clinics despite existed intra-modality, but not inter-modality, difference of manual ROI measures.