Two-voxel MRS with B0 correction using a model-based reconstruction

Performing simultaneous MRS from two-regions is often desirable in spectroscopy studies. However, achieving an optimal B0 shim in two regions is difficult, leading to poor data quality. We investigate a model-based reconstruction for two-voxel MRS, incorporating B0 information, to reconstruct data with reduced T2* decay. We test this approach using least squares and regularization approaches for Hadamard encoding in simulations and phantom. Despite a noise penalty for B0-correction (2-4)-fold, FIDs from two voxels better matched un-broadened spectra under conditions of sufficient SNR. Regularization also produced time-domain reconstructions with less noise than a least-squares approach.