Relevance of KIM-1 and NGAL biomarkers in the diagnosis of persistent kidney failure

Background Group-1 included 45 healthy volunteers, and Group-2 included 45 individuals with CKD, stage 1 to end stage renal failure and were on dialysis. The ELISA method was used to measure the serum levels of NGAL and KIM-1 in each person. Colorimetric techniques were used to measure creatinine, potassium, calcium, serum urea, and random blood sugar (RBS). Version 25 of IBM's statistical software for the social sciences (SPSS) on a Windows platform was used to conduct the statistical study. Using the analysis of variance student t test, patients with CKD were compared to a healthy group; a P ≤ 0. 05 indicated statistical significance. Results: Between individuals with chronic kidney disease and the healthy group, there was a statistically significant variance in NGAL and KIM₁, serum creatinine, urea, potassium, calcium, and RBS. Conclusion: Patients with CRF had considerably higher levels of Neutrophil Gelatinase Associated Lipocalin (NGAL) and Kidney Injury Molecule type 1 (KIM-1), which are diagnostic markers. Abbreviations: CKD - Chronic Kidney Disease; CRF - Chronic Renal Failure; GFR - Glomerular Filtration Rate; KIM-1 - Kidney Injury Molecule -1; NGAL - Neutrophil Gelatinase-Associated Lipocalin; RBS - Random Blood Sugar Keywords: Chronic renal conditions; KIM-1; NGAL Citation: Hasan KY, Al Ammar HAJ. Relevance of KIM-1 and NGAL biomarkers in the diagnosis of persistent kidney failure. Anaesth. pain intensive care 2024;28 (3): 472−480; DOI: 10. 35975/apic. v28i3. 2463 Received: February 29, 2024; Revised: March 10, 2024; Accepted: March 14, 2024