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Abstract A series of some new 1,3,4‐oxadiazole derivatives was synthesized. Hydrazide derivative 4 was reacted with some sugar aldehydes to give the corresponding sugar hydrazones 5 a – c . Acetylation of 5 a – c with acetic anhydride in pyridine, managed the per‐O‐acetyl derivatives 6 a – c while refluxing in acetic anhydride gave the corresponding 1,3,4‐oxadiazolines 7 a – c . On the other hand, 1,3,4‐oxadiazoles 8 a,b, 9, 10, 12, 14 , and 15 were synthesized via the reaction of 4 with different reagents including p ‐chlorobenzoic acid, nicotinic acid, methyl iodide, morpholine, phenyl isothiocyanate, potassium iodide, chloroacetyl chloride, and phosphorus oxychloride, respectively. The new compounds were assessed for their anticancer and antioxidant activities. Compounds 8 a,b, 10 , and 12 – 15 displayed the most antioxidant activity. In addition, compounds 8 a, 8 b , and 13 showed strong cytotoxic activity.
Fadda et al. (Sun,) studied this question.