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In this work, we report the synthesis of cerium vanadate (CeVO4) nanoparticles and their application in modifying screen-printed carbon electrodes (SPCEs) for the electrochemical detection of chloramphenicol (CPC). The physicochemical properties of the CeVO4 nanoparticles were thoroughly investigated by using X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM), confirming their crystallinity and nanostructure. Electrochemical assays demonstrated that the CeVO4-modified SPCE exhibited significantly enhanced electrocatalytic performance toward CPC, as evidenced by the increased peak currents and decreased charge-transfer resistance. A series of experiments involving cyclic voltammetry and differential pulse voltammetry established a diffusion-controlled mechanism for CPC redox reactions on the modified electrode surface. The sensor showed a wide linear range (0.01–550 μM) for CPC detection and a limit of detection (0.002 μM) that was significantly lower than the bare SPCE. Furthermore, the modified electrode displayed excellent selectivity in the presence of potential interfering substances, remarkable stability over repeated cycling, and consistent reproducibility, highlighting the robustness of CeVO4/SPCE as a sensing platform. The integration of CeVO4 nanoparticles into SPCEs presents a significant advancement in the development of sensitive electrochemical sensors for CPC, with potential implications for environmental monitoring, food safety assessment, and clinical diagnostics.
Sriram et al. (Mon,) studied this question.