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Introduction H: HR=1.07, 0.93-1.24) and when further adjusted for BMI, ISI, and CIR (B: HR=1.48, 1.30-1.68; H: HR=1.15, 0.99-1.33). Lower baseline BMI and higher ISI and CIR were protective but did not explain the race/ethnicity effects. Longitudinal relationships of ISI and CIR differed by race/ethnicity (Figure); paradoxically B had the highest CIR which would predict lower diabetes incidence. Conclusion: Higher diabetes incidence in B was not explained by differences in BMI or beta-cell function. We hypothesize that B with prediabetes compensate for other, unknown, risk factors by increasing CIR which, in many, is insufficient to prevent diabetes. Disclosure E. Vazquez Arreola: None. R.L. Hanson: None. W.C. Knowler: None. Funding Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
ARREOLA et al. (Fri,) studied this question.