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Objective: to determine the comparative effectiveness of combination antihypertensive therapy including nitrendipine in patients with essensial hypertension with cognitive impairment. Design and method: The study included 58 male and female patients with I–III AH degree (ESC/ESH, 2018). The average age of the patients was 54.6±10.8 years, the average duration of AH was 8.8±5.52 years. The patients were divided into 2 groups: 1 group – hypertensive patients with cognitive impairment, n=40, 2 group – hypertensive patients without cognitive impairment, n=18. Cognitive function was assessed using the Montreal Cognitive Assessment Scale (MOCA) and Mini-Cog test. Results: Analysis of neuroprotective effectiveness of combined AHT in patients with EH, taking into account the presence/absence of cognitive impairment, revealed that according to the MOCA scale, cognitive functions improved only in 1 st group of patients, initially 22.35± 2.46 points in dynamics - 24.47 ± 2.44 points (p0.05). And also using the Mini-Cog test, it was determined that the scores significantly increased only in 1 st group of patients: initially amounting to 3.75± 1.12 points, over time - 4.35 ± 0.86 (p < 0.02), then as in group 2, there was no significant increase in score. Conclusions: Positive dynamics of cognitive functions against the background of 12 months of AHT with the inclusion of nitrendipine was noted in the subgroup of patients with cognitive impairment.
Yusupova et al. (Wed,) studied this question.