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Abstract Purpose Autologous matrix-induced chondrogenesis (AMIC ® ) and microfracture are established treatments for focal chondral defects in the knee, but there are little clinical data concerning these procedures over the long term. This study evaluates the outcomes of AMIC ® compared to microfracture over 10-year follow-up. Methods Forty-seven patients were randomized and treated either with MFx ( n = 13), sutured AMIC ® ( n = 17) or glued AMIC ® ( n = 17) in a prospective, randomized, controlled multicentre trial. The Modified Cincinnati Knee Score, a visual analogue scale for pain and MOCART score were used to assess outcomes over 10 years post-operatively. Results All treatment arms improved in the first 2 years, but a progressive and significant deterioration in scores was observed in the MFx group, while both AMIC ® groups remained stable. MOCART scores were comparable between groups. Conclusion The AMIC ® procedure results in improved patient outcomes in comparison with microfracture up to 10 years following surgery for the repair of focal chondral defects in the knee. ClinicalTrials.gov Identifier: NCT02993510
Volz et al. (Wed,) studied this question.