Key points are not available for this paper at this time.
The request of "standard TDM" to aid in dosing of substitution drugs in maintenance therapy is rare. Mostly adherence assessment especially in patients with take-home privilege is needed. The laboratory is asked for support if the clinician suspects that the patient: 1. pauses from substitution, 2. spikes substitute into a drug-free "friend-sample", 3. reduces dose, 4. increases dose with illegal substitute, 5. is not in steady state or underdosed or 6. is injecting substitute. These points show different significance for the different substitution drugs:
Neumann et al. (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: