December 8, 2025Journal of Translational Medicine6 citationsOpen Access

Hypoxic migrasomes drive colorectal cancer liver metastasis by mediating CD5L+ macrophage efferocytosis via NRP2/PROX1 axis

YLYuqi Luo YHYiwen Huang YHYAOXING HUANG

Key Points

Hypoxic migrasomes facilitate colorectal cancer liver metastasis by influencing macrophage education.
The study points to macrophages adopting a pro-efferocytic CD5L+ phenotype in response to migrasome signals.
Analysis reveals the role of NRP2/PROX1 axis in reprogramming immune and stromal compartments in metastatic disease.
These findings may enable new therapeutic strategies targeting migrasomes in colorectal cancer advancement.

Abstract

These findings demonstrate that hypoxic CRC-derived migrasomes facilitate liver metastasis by reprogramming stromal and immune compartments, particularly through NRP2/PROX1-mediated education of macrophages toward a pro-efferocytic CD5L⁺ phenotype. Our study reveals a previously unrecognized intercellular communication axis involving migrasomes in CRC progression and provides a potential therapeutic target for metastatic disease.

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Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/69401f002d562116f28f9cd9 https://doi.org/https://doi.org/10.1186/s12967-025-07485-0

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