Dimethylated β-cyclodextrin inclusion complexes containing the guest steroid hormones progesterone and 17β-estradiol: syntheses, crystal structures, thermal analyses and steroid solubility enhancements

Key Points

• To enhance the solubility and delivery of poorly soluble steroid hormones using dimethylated β-cyclodextrin inclusion complexes.
• Synthesis of dimethylated β-cyclodextrin inclusion complexes with progesterone and 17β-estradiol.
• Characterization through crystal structure analysis.
• Thermal analysis to assess stability and solubility improvements.
• Successful formation of inclusion complexes with increased solubility for both progesterone and 17β-estradiol.
• Crystal structures revealed effective incorporation of steroid hormones within the cyclodextrin framework.
• Thermal analyses indicated enhanced stability of the complexes.