Metabolic bariatric surgery decreased mortality by 32% (HR 0.68) in patients aged 60-70 years compared to non-surgical treatment for obesity.
Does metabolic bariatric surgery reduce all-cause mortality in patients > 60 years old with severe obesity compared to non-operative treatment?
Metabolic bariatric surgery in patients over 60 years old with severe obesity is associated with a significant reduction in all-cause mortality, primarily driven by fewer cardiovascular deaths, though the benefit appears to wane for those operated on after age 70.
Absolute Event Rate: 0% vs 0%
Abstract Background Metabolic bariatric surgery leads to improved life expectancy in younger individuals, but whether older (> 60 years) individuals benefit from metabolic bariatric surgery is uncertain. This study examined mortality and causes of death in patients with metabolic bariatric surgery at age 60 years or older. Materials and Methods This was a population-based matched cohort study based on all healthcare in Denmark, Finland, and Sweden between 1996 and 2024. All patients who had primary metabolic bariatric surgery at age > 60 years were included and exactly matched 1:5 to comparison individuals of the same age, sex, country, and calendar year with non-operative treatment for obesity. Cox regression provided hazard ratios with 95% confidence intervals for mortality adjusted for multiple obesity-related diseases and frailty. Results In total, 3879 (16.7%) patients with metabolic bariatric surgery and 19395 (83.3%) patients with non-operative treatment for obesity were included and followed for 176632 person-years. The cumulative mortality was 17.5% ( n = 677) among operated patients compared to 23.5% ( n = 4536) in the non-operated. In adjusted analyses, metabolic bariatric surgery was associated with 32% decreased mortality (HR 0.68, 95% CI 0.63–0.73). The results were consistent in patients of age > 60–70 years at the time of surgery, but there was no apparent benefit in patients operated at age > 70 years (HR 1.14, 95% CI 0.89–1.47). Operated patients were less likely to die from cardiovascular disease (57.6% versus 65.8%, p < 0.001), but other causes of death were similarly distributed between the groups. Conclusion Metabolic bariatric surgery may decrease mortality in older patients with severe obesity.
Gerber et al. (Mon,) reported a other. Metabolic bariatric surgery decreased mortality by 32% (HR 0.68) in patients aged 60-70 years compared to non-surgical treatment for obesity.