Abstract Nowadays, there is a huge challenge linked to multi drugs resistant issue; therefore, researchers are seeking alternatives to antibiotics, such as plants essential oils and extracts. Staphylococcus aureus ( S. aureus ) a pathogenic bacterium, which is associated with several chronic illnesses. Therefore, the ongoing research aimed to examine the chemical profile and biological activity (Quorum sensing inhibition and Antivirulence efficacy) of Eucalyptus globulus essential oil (EgEO) in inhibiting S. aureus survival. EgEO were chemically identified by FTIR and GC-MS assessments. The antibacterial effect of EgEO against the virulent strains was assessed utilizing the disk diffusion method. Eucalyptol (45.20 %) and o-Cymene (25.42 %) were the principal constituents of the studied EgEO. The EgEO is particularly active against the S. aureus strains; with inhibition zones around (50.33 ± 0.57 mm). EgEO is notably able to prevent QS by blocking violacein production in Chromobacterium violaceum (CECT 494), and further reducing the EPS production by 95.40 ± 0.14 %, and biofilm formation by 96.58 ± 0.95 %. Likewise, slime production was affected by EgEO. ADMET of EgEO identified phytocompounds are further confirmed as interesting candidates for additional research and evolution of novel antimicrobial agents. Besides, molecular docking revealed excellent interaction of the detected chemical compounds, targeting some known enzymes involved in QS activities. These findings highlighted the possible employ of EgEO against the pathogenic S. aureus , and block infection promoting factors regulated by QS mechanism.
Tabti et al. (Thu,) studied this question.