What question did this study set out to answer?

To evaluate the effects of total pancreatectomy and islet auto transplantation on health outcomes in patients with hereditary pancreatitis.

January 22, 2026

Total Pancreatectomy and Islet Auto Transplantation in South Australia: A Preliminary Evaluation of a 10‐Year Experience

Key Points

To evaluate the effects of total pancreatectomy and islet auto transplantation on health outcomes in patients with hereditary pancreatitis.
Evaluated 15 patients who underwent total pancreatectomy and islet auto transplantation.
Monitored hospital admissions, inpatient days, emergency visits, and analgesic use.
Assessed insulin independence and overall quality of life.
Marked reduction in hospital admissions and inpatient days.
Complete cessation of analgesics in most patients by 24 months.
Nearly half of the patients achieved durable insulin independence.

Abstract

ABSTRACT Hereditary pancreatitis causes severe early‐onset pain and hospitalisation. In 15 Australian patients undergoing total pancreatectomy and islet auto transplantation (TPIAT), we observed a marked reduction in hospital admissions, inpatient days and emergency visits, complete analgesic cessation by 24 months and durable insulin independence in nearly half of the patients. These findings highlight TPIAT’s potential to improve quality of life and reduce healthcare burden. Our programme aims to build evidence to support public funding and ensure equitable access to this procedure.

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Cite This Study

Radisic et al. (Thu,) studied this question.

synapsesocial.com/papers/6971bd4c642b1836717e1f89 https://doi.org/https://doi.org/10.5694/mja2.70129

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