Depression is a prevalent and debilitating mental illness with a persistent sense of hopelessness and a lack of enthusiasm for day-to-day activities. Curcumin has garnered attention due to its putative antidepressant properties as well as its neuroprotective, anti-inflammatory, and antioxidant properties. Pro-inflammatory cytokines have been found to increase the intensity of depressed symptoms, and recent investigations have demonstrated the important role that neuroinflammation plays in the development and maintenance of depression. This review explored the neuroinflammatory mechanisms associated with depression. It elucidated the multifaceted actions of curcumin, including inhibition of the NLRP3 inflammasome, modulation of the kynurenine pathway, and reduction of inflammatory markers in the brain. Evidence from clinical trials and meta-analyses suggests that curcumin can significantly alleviate depressive symptoms, making it a promising adjunctive treatment for major depressive disorder. By addressing the underlying neuroinflammatory processes, curcumin offers a novel approach that could improve patient outcomes in managing depression.
Singh et al. (Tue,) studied this question.