ABSTRACT Objective This study aimed to compare salivary levels of galectin‐8, galectin‐9, and RANKL in individuals with gingivitis, periodontitis, and healthy periodontium, and to evaluate their diagnostic potential in periodontal diseases. Methods A total of 60 systemically healthy, non‐smoking individuals were included in this cross‐sectional study. Participants were divided into three groups based on periodontal examination: healthy (Group H, n = 20), gingivitis (Group G, n = 20), and periodontitis (Group P, n = 20). Clinical periodontal parameters were recorded. Salivary biomarker levels were analyzed using ELISA. Results All biomarkers were significantly elevated in groups G and P compared to group H ( p 0.05). Conclusion Salivary galectin‐8, galectin‐9, and RANKL levels are elevated in periodontal disease and may serve as diagnostic biomarkers. Among them, galectin‐9 demonstrated superior discriminative power for identifying periodontal disease. Trial Registration NCT06404476
Er et al. (Mon,) studied this question.