P1300 Transition of Pediatric-Onset Inflammatory Bowel Disease to Adult Care: A Multicenter Italian Cohort Study

Abstract Background Our results provide new insights into the clinical and epidemiological profile of pediatric IBD in Italy. These findings underscore the importance of early diagnosis and coordinated pediatric–adult transition pathways to optimize long-term outcomes. Methods This multicenter retrospective study was conducted in nine IBD referral centers, all with a structured transition clinic. Patients who completed transition between January 2014 and January 2024 were included. Data were collected from medical records. Results A total of 298 patients were enrolled (F 146, M 152), including 153 UC, 146 CD, and 1 IC (later reclassified as UC). Median age at diagnosis was 13 years (IQR 2–17). A total of 58 extra-intestinal manifestations (EIMs) were identified: articular (18), cutaneous (19), ocular (2), hepatic (18), and other (1). Forty-two patients underwent surgery, including 7 for perianal disease. From diagnosis to transition, UC extension occurred in 6 patients (3.9%): 2 from E1 to E2, 3 from E2 to E3, and 1 from E1 to E3. In CD, disease behavior progressed in 5 patients (3.4%) B1→B2 n = 3, B2→B3 n = 1, B1→B3 n = 1—while location extension to L3 occurred in 6 (4.1%; L1→L3 n = 2, L2→L3 n = 4). Overall, 143 patients (48.0%) were receiving biologic therapy (IFX, ADA, VDZ, UST, or Anti-JAK) at transition. Median diagnostic delay was 3 months (IQR 0–84), with no significant difference between UC and CD (p = 0.17). Regarding the type of transition, 161 patients underwent a single combined visit, 90 had a single combined visit plus referral letter, 17 a double combined visit, 2 transitioned via referral letter only, and 28 maintained follow-up with the same professional. At 12-month follow-up (n = 234), 55 therapy changes were recorded (25 CD, 30 UC), along with 3 new surgeries (CD), 2 UC extensions (E2→E3), and 4 new EIMs (3 dermatologic, 1 articular). Conclusion Our results provide new insights into the clinical and epidemiological profile of pediatric IBD in Italy. These findings underscore the importance of early diagnosis and coordinated pediatric–adult transition pathways to optimize long-term outcomes. Conflict of interest: Dr. Orrù, Giorgia: No conflict of interest Onidi, Maria Francesca: No conflict of interest Ceccarelli, Linda: No conflict of interest Felice, Carla: No conflict of interest Bodini, Giorgia: No conflict of interest Gaiani, Federica: No conflict of interest Gravina, Antonietta Gerarda: No conflict of interest Ribaldone, Davide Giuseppe: No conflict of interest Sigon, Riccardo: No conflict of interest Tonello, Cinzia: No conflict of interest Zolfino, Teresa: No conflict of interest Corpino, Mara: No conflict of interest Congia, Mauro: No conflict of interest Locci, Giorgia: No conflict of interest Tamponi, Elisabetta: No conflict of interest Manunza, Romina: No conflict of interest Runfola, Matteo: No conflict of interest Argiolas, Giovanni Maria: No conflict of interest Usai Satta, Paolo: No conflict of interest Savarino, Edoardo Vincenzo: No conflict of interest Mocci, Giammarco: No conflict of interest