Cassia-Derived Natural Flavonoids as Multi-Target Candidates for Lung Cancer Therapy: A Network Pharmacology and Molecular Modeling Study.

Key Points

• To explore the potential of Cassia-derived flavonoids as multi-target agents for lung cancer therapy.
• Utilized network pharmacology to identify targets relevant to lung cancer.
• Applied molecular modeling to assess interactions of flavonoids with identified targets.
• Predicted safety and efficacy profiles of the flavonoids.
• Identified PTGS2, KIT, and XDH as key targets for flavonoids in lung cancer.
• Flavonoids showed favorable interaction profiles with these targets.
• Safety predictions indicate promising characteristics for further testing.