The effects of hypoxia inducible factor-1α in myeloid cells and a high-salt diet in a mouse model of orthodontic tooth movement

Key Points

• This research aims to understand how hypoxia inducible factor-1α affects orthodontic tooth movement in the context of a high-salt diet.
• Utilized a mouse model to analyze orthodontic tooth movement (OTM).
• Assessed the effects of a high-salt diet on OTM rates.
• Evaluated the role of myeloid cell-derived HIF1α in OTM under high-salt conditions.
• A high-salt diet and lack of HIF1α both resulted in increased OTM.
• OTM was primarily influenced by high-salt conditions regardless of HIF1α levels in myeloid cells.