ABSTRACT Background At‐risk mothers experience disproportionately higher rates of antenatal depression and anxiety, which can hinder mother–infant bonding and adversely affect infant socioemotional development. Despite growing evidence on postpartum mental health, antenatal risk factors among psychosocially vulnerable mothers remain underexplored, particularly in multi‐ethnic Asian settings. Aim To identify factors associated with antenatal depression, anxiety, and maternal–fetal bonding among at‐risk mothers. Methods This cross‐sectional observational study was nested within an ongoing randomised controlled trial. Two hundred at‐risk mothers, defined as single, of low socioeconomic status, referred for psychosocial support, at risk of depression, with adverse childhood experiences, or with a fetus with a congenital malformation, were recruited from outpatient obstetric clinics between February and September 2024. Participants completed online self‐administered questionnaires assessing antenatal depression, anxiety, perceived stress, social support, parenting self‐efficacy, and maternal–fetal bonding. General Linear Models were used to analyse data and identify factors associated with depression, anxiety, and bonding. Results Higher perceived stress was associated with increased depression ( β = 0.28, p < 0.001) and anxiety ( β = 1.28, p < 0.001) and poorer bonding ( β = 0.08, p = 0.02), while greater social support predicted lower anxiety ( β = −0.31, p < 0.001). Higher parenting self‐efficacy was linked to stronger bonding ( β = −0.09, p = 0.06). Younger mothers ( β = −2.68, p = 0.025) and Indian mothers ( β = 7.46, p = 0.017) were particularly vulnerable to anxiety, whereas post‐secondary education was protective against depression ( β = −1.44, p = 0.02). Model fit ranged from 0.14 to 0.65. Conclusion Perceived stress, social support, and parenting self‐efficacy significantly influenced antenatal mental health and bonding in at‐risk mothers. These findings underscore the need for culturally sensitive, nurse/midwife‐led interventions that integrate early screening, stress reduction, and empowerment strategies within routine antenatal care to strengthen maternal mental health and early bonding outcomes. Implications for the Profession and/or Patient Care (1) Nurses and midwives play a critical role in screening for antenatal depression and anxiety in mothers with risk profiles highlighted in this study. (2) Culturally responsive nursing practice that demonstrates sensitivity towards sociocultural pressures is needed to provide individualised care. (3) Integration of digital and community‐based antenatal education programs could provide more equitable access to care for at‐risk mothers who may face barriers to in‐person care. Impact (1) Despite having a higher susceptibility for antenatal mental health conditions, risk factors for antenatal depression, anxiety, and maternal–infant bonding have been underexplored in at‐risk mothers. (2) Antenatal stress and anxiety are universally associated with depression across risk groups, while maternal self‐efficacy and perceived social support serve as key protective factors. (3) The findings from this study suggest the need for early screening and nurse‐led interventions that support maternal parenting self‐efficacy and stress management to improve maternal mental health outcomes among at‐risk mothers. Reporting Method STROBE reporting checklist. Patient or Public Contribution No patient or public contribution.
Ng et al. (Thu,) studied this question.
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