February 2, 2026Open Access

Prevalence and prognostic value of elevated soluble urokinase plasminogen activator receptor (suPAR) in patients admitted with acute heart failure

Key Result

Elevated suPAR levels at hospital admission in acute heart failure patients are significantly correlated with increased one-year mortality risk.

Key Points

To examine the relationship between soluble urokinase plasminogen activator receptor (suPAR) levels and mortality risk in acute heart failure (AHF) patients.
Measured suPAR levels at hospital admission
Evaluated correlation with one-year mortality risk
Considered integration into multimodal prognostication approach
Elevated suPAR levels correlate significantly with increased one-year mortality risk in AHF patients
Suggests potential for early identification of high-risk patients

Structured PICO

Does elevated suPAR level at admission predict 365-day all-cause mortality in patients with acute heart failure?

Population

386 patients admitted with acute heart failure (AHF) to the emergency department, median age 76.5 years, 43.5% female, in Denmark.

Intervention

Measurement of soluble urokinase plasminogen activator receptor (suPAR) levels at hospital admission (stratified as high ≥ 6 ng/ml)

Comparator

Low suPAR levels (< 6 ng/ml)

Outcome

365-day all-cause mortalityhard clinical

Elevated suPAR levels at hospital admission in AHF patients are independently associated with increased one-year mortality and outperform CRP for prognostication.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

SuPAR levels measured at hospital admission in AHF patients correlate significantly with one-year mortality risk. Potentially, suPAR could be integrated as a part of an early multimodal prognostication mode of AHF to identify high-risk patients.

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