Bidirectional nexus between metabolic disease and aortic valve calcification: from pathogenic mechanisms to integrated multimorbidity management

Key Points

• Explore the connections between metabolic disease and aortic valve calcification to improve treatment strategies.
• Review of current treatment practices for metabolic disease and aortic valve calcification.
• Analysis of potential targeted drugs for specific pathways.
• Discussion on integrated multimorbidity management.
• Current treatment relies mainly on valve replacement surgery.
• There is a need for early co-governance strategies to address multiple diseases.
• Targeted therapies are expected to enhance management beyond existing methods.

Abstract