What question did this study set out to answer?

To assess the impact of various sedative-analgesic combinations on fatigue experienced after gastrointestinal endoscopy.

February 2, 2026Annals of Medicine1 citationsOpen Access

Effects of nine sedative-analgesic combinations on fatigue after gastrointestinal endoscopy: a randomized controlled 3 × 3 factorial trial protocol

To assess the impact of various sedative-analgesic combinations on fatigue experienced after gastrointestinal endoscopy.
Conduct a randomized controlled trial
Utilize a 3×3 factorial design
Compare fatigue levels among nine different sedative-analgesic combinations
Findings will indicate which combinations lead to the least fatigue post-procedure
Quantitative data on fatigue levels will be analyzed

Chinese Clinical Trial Registry (ChiCTR2500112657; registered on November 18, 2025).

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