The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides

Key Points

• The research aims to understand how peptide size affects the identification of potent binders in mRNA display techniques.
• Analyzed the relationship between peptide size and binding affinity in mRNA display screens
• Conducted experiments to evaluate varying peptide sizes during the binder identification process
• Found that larger peptides generally have a higher likelihood of being potent binders
• Identified a balance between peptide size and binding efficiency for optimal discovery outcomes