Primary Cardiac T-cell Lymphoma Presenting as ST-elevation Myocardial Infarction with Fatal Ventricular Arrhythmias: A Case Report

Abstract Background Primary cardiac T-cell lymphoma is an extremely rare subtype of primary cardiac lymphoma. Due to the paucity of clinical data, it poses a challenge from diagnosis to management. Case Summary A 65-year-old female presented with dyspnea and epigastric pain. Her electrocardiogram revealed an ST-elevation in leads II, III, aVF, and from V4-V6, for which she underwent an emergent coronary angiogram, which revealed normal coronaries. Further multimodality cardiac imaging demonstrated a large right ventricular mass infiltrating the inferior wall of the left ventricle. A percutaneous transvenous biopsy was done, and results confirmed an anaplastic T-cell lymphoma, which prompted the initiation of chemotherapy. Unfortunately, her course became more complicated despite notable reduction in the mass size on follow-up imaging, as she had an incessant, unstable ventricular tachycardia unresponsive to medical therapy, which led to death within three months of presentation. Discussion PCTCL has unpredictable presentations. A biopsy is required to reach a definitive diagnosis, alongside multimodality cardiac imaging. Moreover, left ventricular involvement may directly influence survival in PCL and potentially indicate an advanced and fatal stage.