Skeletal diversity-oriented synthesis of cycloheptatriene b indole, spiro-cyclopentene b indole and carbazole derivatives via Pd-catalyzed sequential reaction involving indolyl allene intermediates

Key Points

• The aim is to develop a Pd-catalyzed method for synthesizing various polycyclic indole derivatives.
• Employs a Pd-catalyzed, base-controlled divergent cyclization strategy.
• Utilizes 3-propargyl indoles and ortho-iodophenyl-ynones as substrates.
• Allows tuning of the reaction pathway for desired products.
• Successfully synthesizes cycloheptatriene indole, spiro-cyclopentene indole, and carbazole derivatives.
• Demonstrates effective control over product formation through reaction conditions.