What question did this study set out to answer?

To explore the diversity of archaea in the Estonian gut microbiome.

February 8, 2026Open Access

Human gut archaea collection from Estonian population

Key Points

To explore the diversity of archaea in the Estonian gut microbiome.
Analyzed 1,878 fecal microbiome samples from the Estonian Microbiome Deep cohort.
Reconstructed metagenome-assembled genomes from metagenomic reads.
Curated 273 archaeal MAGs into a comprehensive database.
Identified 273 archaeal MAGs representing 21 species and 144 strains.
Created the EstMB MAGdb Archaea-273 collection for future research.

Abstract

While microbiota plays a crucial role in maintaining overall health, archaea, a component of microbiota, remain relatively unexplored. Here, we present a newly assembled set of archaeal metagenome-assembled genomes (MAGs) from 1,878 fecal microbiome samples. These MAGs were reconstructed from metagenomic reads of the Estonian Microbiome Deep (EstMB-deep) cohort, which were reused here specifically for archaeal MAG reconstruction. We identified 273 archaeal MAGs, representing 21 species and 144 strains which we curated into the “EstMB MAGdb Archaea-273” MAGs collection.

Human gut archaea collection from Estonian population

Key Points

Abstract

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