Cyanidin-3-O-glucoside promotes late-stage venous thrombus resolution in mice, accompanied by reduced macrophage M1-associated inflammation and attenuated HIF-1α-linked signaling

Key Points

• The study aims to investigate the effects of cyanidin-3-O-glucoside on venous thrombus resolution and associated inflammation.
• Utilized a mouse model of deep vein thrombosis
• Administered cyanidin-3-O-glucoside
• Analyzed macrophage polarization
• Evaluated HIF-1α signaling pathways
• Cyanidin-3-O-glucoside significantly promoted late-stage thrombus resolution
• Reduced macrophage M1-associated inflammation was observed
• Attenuated HIF-1α-linked signaling pathways were noted in treated mice