Higher hsCRP levels (>1.0mg/dL) independently predicted increased risk of recurrent cardiovascular events in 1719 CAD patients over 7.3 years (p<0.0001).
Do higher hsCRP levels predict cardiovascular events in patients with coronary artery disease?
Higher hsCRP concentrations in patients with coronary artery disease are independently associated with an increased risk of recurrent cardiovascular events.
Absolute Event Rate: 0% vs 0%
Abstract Introduction The prognosis of cardiovascular disease can be predicted through various indicators, such as biochemical, imaging and genetic. High sensitivity C reactive protein (hsCRP) is a valuable inflammatory biomarker in clinical conditions such as coronary artery disease (CAD). CRP biomarkers are easy to get, cheap, and sensitive for predicting deleterious events. Objective To investigate the association between hsCRP levels and the risk of vascular and non-vascular outcomes in a Southern European population with CAD. Methods We performed a prospective study englobing 1719 CAD patients with an extended follow-up median of 7.3±6.0 years. All demographic, biochemical, and clinical data, as well as hsCRP levels, were collected. The outcome was cardiovascular (CV) events occurrence myocardial infarction or unstable angina, ischemic stroke, new admission by heart failure, revascularization (angioplasty, CABG) or cardiovascular death. HsCRP levels were stratified into quintiles below 1.0mg/dL (1stQ hsCRP≤0.12mg/dL; 2ndQ hsCRP 0.12-0.25mg/dL; 3rdQ hsCRP 0.25-0.26mg/dL; 4thQ hsCRP 0.26-0.37mg/dL and 5thQ hsCRP 0.37-1.0mg/dL and above 1.0mg/dL. Associations between baseline hsCRP concentrations and primary outcome were assessed using Cox proportional hazard models adjusted for all confounders (age, sex, smoking status, diabetes, body mass index, hypertension, dyslipidemia, physical inactivity, alcohol and CAD family history). Kaplan-Meier estimated differences in the survival probability in each hsCRP quintile and the subgroup 1.0mg/dL. Results The Kaplan-Meier event curves displayed ongoing divergence of the hsCRP quintiles groups below 1.0mg/dL and above 1.0mg/dL. After Cox regression analysis, physical inactivity (p=0.001), alcohol (p=0.049), and hsCRP (p0.0001) remained in the equation as significantly associated with CV events. Specifically, the significances were: p=0.023 for 2ndQ; p=0.020 for 3rdQ; p=0.002 for 5thQ and p0.0001 for hsCRP10mg/dL. HsCRP 4thQ did not reach statistical significance. The risk demonstrated by hsCRP levels for CV events is more significant than the previously established cardiovascular risk factors. Conclusion Our findings demonstrated that higher hsCRP concentrations in coronary patients were independently associated with an increased risk of recurrent CV events. As a biomarker, hsCRP highlights the importance of inflammation in cardiovascular disease.
Abreu et al. (Sat,) reported a other. Higher hsCRP levels (>1.0mg/dL) independently predicted increased risk of recurrent cardiovascular events in 1719 CAD patients over 7.3 years (p<0.0001).