What question did this study set out to answer?

This research investigates how environmental ciprofloxacin affects pregnancy outcomes, particularly miscarriage.

February 9, 2026Open Access

Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation

Key Points

This research investigates how environmental ciprofloxacin affects pregnancy outcomes, particularly miscarriage.
Assessment of ciprofloxacin exposure on pregnancy outcomes in a defined model.
Analysis of senescence markers in relation to miscarriage.
Evaluation of TRIM21-mediated MFF degradation pathways.
Ciprofloxacin exposure is linked to increased pregnancy loss.
Senescence processes are implicated in mediating miscarriage.
TRIM21 plays a crucial role in the degradation of MFF, contributing to adverse pregnancy outcomes.

Abstract

This work was supported by the NSFC (NSFC No. 82373602 and No. 82571347), SMRF (No. B2303002), GBABRF (2023B1515120054 and 2023A1515110497), NSFC Joint Fund Key Support Project (grant no. U24A20748), the JITCBR (202407), HCGP (A2024281), SSTP (No. JCYJ20220530144403008, JCYJ20220818103607015, JCYJ20230807111401002, JCYJ20240813180400002, and JCYJ20241202152800001), CRSFFWJMF 320.6750.2022-06-47, FHRP (No. FTWS011 and FTWS2022002).

Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation

Key Points

Abstract

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