What question did this study set out to answer?

Evaluate the anticancer effects of hesperetin when combined with cisplatin in cancer and normal cell lines.

February 11, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

Investigation of the Anticancer Effects and Senescence Induction of Hesperetin Combined with Cisplatin in Hepatocellular Carcinoma and Embryonic Fibroblast Cell Lines

AAAnif Nur Artanti RJRiris Istighfari JenieUniversitas Gadjah Mada RRRumiyati RumiyatiUniversitas Gadjah Mada

Key Points

Evaluate the anticancer effects of hesperetin when combined with cisplatin in cancer and normal cell lines.
Co-treatment of hepatocellular carcinoma and embryonic fibroblast cell lines with hesperetin and cisplatin.
Assessment of cell viability and senescence induction.
Co-treatment significantly reduces cancer cell viability.
Normal fibroblasts are protected from senescence with the treatment.

Abstract

These results suggest that HST and Cisp co-treatment synergistically reduces cancer cell viability while protecting normal fibroblasts from senescence, supporting its potential as a co-chemotherapeutic agent in HCC treatment, while also serving as a protective agent against senescence in healthy tissues.

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Cite This Study

Artanti et al. (Sun,) studied this question.

synapsesocial.com/papers/698c1c73267fb587c655efc1 https://doi.org/https://doi.org/10.31557/apjcp.2026.27.2.557

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