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Significance Sex determination is one of the most fundamental but also extraordinary plastic processes in nature. Many different master sex-determining genes have been characterized in vertebrates, and most of them are known to fulfill essential functions during sexual development and thus are already tightly linked to the process that they now govern. Only one exception is currently known: the salmonid master sex-determining gene ( sdY ), which arose from the duplication of an immune-related gene. Here we show that SdY prevents female differentiation by interacting and blocking the action of a key ovarian differentiation factor. These results suggest that the evolution of unusual vertebrate master sex determination genes is strongly constrained by their ability to interact with the canonical gonadal differentiation pathway.
Bertho et al. (Wed,) studied this question.
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