Unveiling TP5 dual binding mechanism and structure-based search for potential dual inhibitors of Tubulin and PD-L1

Key Points

• This research aims to explore the dual binding mechanism of TP5 and identify potential inhibitors for tubulin and PD-L1.
• Investigated the structural characteristics of TP5 binding to tubulin and PD-L1.
• Conducted a structure-based search for potential dual inhibitors.
• Analyzed microtubule dynamics and immune response indicators.
• Identified a novel dual binding site for TP5 on tubulin and PD-L1.
• Discovered potential inhibitors that effectively disrupt both microtubule dynamics and PD-L1 mediated immune evasion.