In this cross-sectional analysis of multimodal data in acute ischemic stroke, tissue signal intensities showed stronger time-dependence than volumetric measures, supporting the view that infarct evolution reflects progressive tissue injury rather than consistent volumetric expansion. This suggests that "infarct growth rate" concepts may be more applicable to NCCT and DWI as parameters of tissue demise rather than to perfusion-based metrics.
Urbach et al. (Wed,) studied this question.