Hypomagnesemia significantly prolonged ventricular repolarization parameters, including QTc interval (431.72 ms vs 414.55 ms) and Tp-e interval (95.31 ms vs 82.88 ms), compared to normomagnesemia.
Case-Control (n=160)
No
Does hypomagnesemia increase ventricular repolarization heterogeneity and prolong repolarization parameters compared to normomagnesemia in adults without structural heart disease?
Hypomagnesemia is independently associated with increased ventricular repolarization heterogeneity (prolonged QTc and Tp-e intervals), suggesting it may serve as a simple biomarker for elevated arrhythmogenic risk.
Effect estimate: Cohen's d 0.95
Absolute Event Rate: 431.72% vs 414.55%
p-value: p=<0.001
Abstract This study investigated the changes in ventricular repolarization parameters assessed by electrocardiography (ECG) in the presence of hypomagnesemia and the relationship between these parameters and serum magnesium levels. A total of 160 individuals were included in this retrospective, observational study, who were divided into two groups according to serum magnesium levels: hypomagnesemia group ( n = 80; serum Mg < 1.7 mg/dL) and normomagnesemia control group ( n = 80; serum Mg 1.8–2.2 mg/dL). The two groups were matched for age and gender. Ventricular repolarization parameters such as QT, corrected QT (QTc), T peak-to-T end interval (Tp-e), Tp-e/QT, Tp-e/QTc, QRS duration, and heart rate were measured from the ECG recordings of all participants and compared. In the hypomagnesemia group, QT, QTc, Tp-e, Tp-e/QT, and Tp-e/QTc parameters were significantly prolonged compared to the control group (for all p < 0.001). A significant negative correlation was found between serum magnesium level and QTc ( r = − 0.437), Tp-e ( r = − 0.457), Tp-e/QT ( r = − 0.288), and Tp-e/QTc ( r = − 0.281). In multivariate regression analyses, magnesium level was determined as an independent predictor for both QTc duration (β = − 20.3, p < 0.001) and Tp-e/QTc ratio (β = − 0.048, p = 0.001), despite controlling for potential confounding variables. The findings show that serum magnesium level is independent and clinically significant on ventricular repolarization duration and heterogeneity. Hypomagnesemia was associated with alterations in ventricular repolarization parameters, reflecting increased repolarization heterogeneity. Our findings suggest that low serum magnesium is independently associated with prolonged Tp-e/QTc and QTc intervals, highlighting its role in ventricular repolarization heterogeneity.
Aslan et al. (Tue,) conducted a case-control in Hypomagnesemia (n=160). Hypomagnesemia vs. Normomagnesemia (1.8-2.2 mg/dL) was evaluated on QTc interval (ms) (Cohen's d 0.95, p=<0.001). Hypomagnesemia significantly prolonged ventricular repolarization parameters, including QTc interval (431.72 ms vs 414.55 ms) and Tp-e interval (95.31 ms vs 82.88 ms), compared to normomagnesemia.