Abstract PS4-08-16: Evaluation of Clinicopathological Features and Prognoses of Male Patients with Breast Lymphoma

Abstract Background: Primary breast lymphoma is an extremely rare malignancy, and its occurrence in male patients is even less common, with limited published data available. Due to its rarity, the clinicopathological characteristics and prognostic factors in male breast lymphoma remain poorly understood. Better characterization of this unique patient group may contribute to more tailored diagnostic and therapeutic approaches. This study aimed to evaluate the clinicopathological features and prognoses of patients diagnosed with male breast lymphoma. Method: Data for this study were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, covering cases of male breast lymphoma diagnosed between 2000 and 2021. Demographic, clinicopathological, and survival data were collected and analyzed. Survival outcomes were assessed using Kaplan-Meier curves with the log-rank test. Results: A total of 138 patients were included in the study. 86 (62.3%) of the patients were over 65 years of age. The race of 122 (88.4%) patients was white. The disease was detected in the right and left breast at a similar rate (Right- 48.6%, Left - 47.1%). The most common histopathological types were Diffuse Large B Cell Lymphoma (39.1%), MALT (mucosa-associated lymphoid tissue) lymphoma (23.9%), and Follicular lymphoma (17.4%), respectively. According to the Ann Arbor staging system, the valid percentage of Stage 1 disease was 48.8% and the rate of Stage 2 disease was 21.3%. Breast surgery was performed in 30.4% of the patients, as a valid percentage, the rate of patients who received radiotherapy was 31.2% and the rate of patients who received chemotherapy was 44.9%. B symptoms were present in 6.7% of the patients. The 5-year and 10-year survival rates were 71.7% and 55.7%, respectively. In the prognostic evaluation of the factors affecting survival; age (p0.001), tumor side (p=0.727), race (p=0.539), origin (p=0.888), presence of B symptom (p=0.778), lymphoma type (p0.001), stage (p=0.040), breast surgery (p=0.555), radiotherapy (p=0.033), chemotherapy (p=0.017) were determined. Conclusion: Male breast lymphoma is quite rare and is more common in the elderly population. Age, type of lymphoma, and tumor stage were identified as prognostic factors. Receiving chemotherapy and radiotherapy in treatment has a positive effect on prognosis. Citation Format: A. Azizy, I. Dogan, M. Bozkurt, O. Dülgeroglu, S. Yücel, I. Yıldız, I. D. Subası, A. Arican, C. Uras. Evaluation of Clinicopathological Features and Prognoses of Male Patients with Breast Lymphoma abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS4-08-16.