In vitro gastric organoid models offer important insights into human-specific characteristics of the stomach that are required for understanding stomach development. In their work, Daniel Kechele and colleagues show that human antral gastric organoids, mixed with exogenous splanchnic mesenchyme and neural crest cells, can faithfully model the multi-layered complexity and inter-layer signalling pathways of human stomach development. To learn about their work, we spoke to the first and corresponding author, Daniel Kechele, Staff Scientist at Cincinnati Children's Hospital, USA.
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