Evaluating the role of morphology, immunophenotyping and karyotyping in NPM1 measurable residual disease surveillance in acute myeloid leukaemia | Synapse
February 22, 2026
Evaluating the role of morphology, immunophenotyping and karyotyping in NPM1 measurable residual disease surveillance in acute myeloid leukaemia
Key Points
This research aims to evaluate the role of ancillary diagnostic tests in monitoring NPM1 measurable residual disease in acute myeloid leukaemia.
Evaluated the relevance of morphology, immunophenotyping, and karyotyping in MRD surveillance
Focused on diagnostic tests conducted on bone marrow samples
Questioned the utility and effectiveness of these tests for monitoring disease status
Showed potential benefits of using morphology and immunophenotyping in predicting MRD outcomes
Indicated that certain diagnostic tests may enhance monitoring of disease in patients with acute myeloid leukaemia
Abstract
Aim: Given the high sensitivity of NPM1 measurable residual disease (MRD), we questioned the utility of ancillary bone marrow (BM) diagnostic tests in NPM1 MRD surveillance.