Plasmablastic lymphoma (PBL) is a very rare and aggressive type of large B-cell lymphoma with poor clinical outcomes. It often presents in extranodal locations and is typically seen in immunosuppressed adults, especially those with Epstein-Bar virus (EBV) or human immunodeficiency virus (HIV) infection. This case study describes a 58-year-old male with no prior history of immunosuppression, who presented with bilateral infective testicular changes with an incidental discovery of a left testis mass. Subsequent histology demonstrated a sheet-like infiltrate of plasmacytoid cells with numerous large markedly atypical, anaplastic and multinucleated forms present. Frequent mitoses, scattered apoptotic bodies and foci of necrosis were noted. Immunohistochemistry showed a complete absence of B-cell marker expression, strong positivity for plasma cell-associated markers and high Ki-67. Molecular studies showed the presence of MYC gene rearrangement. This unique case highlights the correlation of clinical, radiological, histological, immunohistochemical and molecular findings in the unusual diagnosis of PBL within the testis of an immunocompetent patient.
Chan et al. (Sun,) studied this question.