What question did this study set out to answer?

This research aims to evaluate the effectiveness of a multimarker calculator in predicting short-term mortality and clinical deterioration in patients with acute pulmonary embolism.

February 22, 2026

Performance of the multimarker calculator for predicting short-term deterioration and mortality in a chinese prospective multicenter pulmonary embolism cohort

Key Points

This research aims to evaluate the effectiveness of a multimarker calculator in predicting short-term mortality and clinical deterioration in patients with acute pulmonary embolism.
Conducted a prospective multicenter cohort study in China
Monitored hemodynamically stable patients with acute pulmonary embolism
Utilized a multimarker calculator to assess outcomes
Collected and analyzed data on mortality rates and clinical deterioration events
Identified 80% of acute pulmonary embolism deaths occurring in stable patients
Demonstrated that timely identification of deterioration may reduce mortality
Showed improvement in risk stratification using the multimarker calculator

Abstract

Extract Acute pulmonary embolism (PE) is the third leading cause of cardiovascular emergencies 1 and the leading cause of unexpected in-hospital death in China 2. Notably, approximately 80% of acute PE-related deaths occur in hemodynamically stable patients 1, 3. Moreover, patients who die from PE are often not promptly alerted during rapid clinical deterioration 4. Timely and precise identification of clinical deterioration, including death, may help reduce mortality 5.

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Cite This Study

Gao et al. (Thu,) studied this question.

synapsesocial.com/papers/699a9ceb482488d673cd2b06 https://doi.org/https://doi.org/10.1183/13993003.02124-2025

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