Synthesis of (1R, 6R)-7,7-Dimethyl-3-Azabicyclo4.1.0Heptan-4-One

Key Points

• The aim is to synthesize 7,7-dimethyl-3-azabicyclo[4.1.0]heptan-4-one from simpler precursors.
• Used intramolecular cyclization to form the target compound.
• Started with acyclic precursors derived from (+)-3-karen.
• Employed two different methods to achieve cyclization.
• Successfully synthesized 7,7-dimethyl-3-azabicyclo[4.1.0]heptan-4-one.
• Demonstrated the feasibility of the synthesis through the two methods.