Synthesis of Grico Lactone and Its Enantiomer

Key Points

• The aim is to synthesize Grieco lactone and its enantiomers from specific diastereomeric precursors.
• Performed a two-step synthesis process.
• Used diastereomeric 2,2-dichloro-2-[(1,5)-5-hydroxycyclopent-2-en-1-yl]-N-[(1)-1-phenylethyl]acetamides as starting materials.
• Measured the total yield of the synthesized enantiomers.
• Achieved a total yield of 77% for the Grieco lactone synthesis.
• Successfully obtained the enantiomers during the synthesis process.