The dose-dependent performance of the DL-based algorithm suggests sensitivity to the characteristics of the training data used to develop the DL model. The findings demonstrate distinct differences in the noise suppression behavior between DL-based and conventional methods in DR and underscore the importance of detailed frequency-domain evaluation for understanding advanced image processing. Further research is warranted to integrate noise analysis with diagnostic performance metrics to comprehensively assess clinical utility.
Maruyama et al. (Sun,) studied this question.