Impact of Thiazides and Fluoropyrimidines Interaction on Myelotoxicity and Other Adverse Events in Real-World Practice: A Retrospective Cohort Study. | Synapse
March 1, 2026
Impact of Thiazides and Fluoropyrimidines Interaction on Myelotoxicity and Other Adverse Events in Real-World Practice: A Retrospective Cohort Study.
Key Points
To evaluate how thiazides and fluoropyrimidines interact and affect myelotoxicity and other adverse events in real-world settings.
Conducted a retrospective cohort analysis
Utilized data from Spanish Clinical Studies Registry and EMA-RWD Catalogs
Assessed myelotoxicity and adverse events in patients
Found significant impacts of thiazide and fluoropyrimidine interactions on myelotoxicity
Identified various adverse events related to this drug interaction
Results indicate the necessity for careful monitoring of patients receiving these treatments.
Abstract
The protocol was submitted and approved at the Spanish Clinical Studies Registry (REEC ID: 0050-2024-OBS) and the EMA-RWD Catalogs (ID: 1000000181).