Bioorthogonal catalytic centres engineered for gastrointestinal stabilization provide oral delivery for the treatment of gastric cancer
Key Points
To evaluate the effectiveness of engineered exoshells for oral delivery in treating gastric cancer.
Conducted in vitro tests to assess efficacy of exoshells.
Performed in vivo experiments to evaluate the therapeutic potential in gastric cancer models.
Analyzed the stability and titratability of the exoshells as a treatment platform.
Exoshells showed significant potential for oral administration.
Demonstrated a titratable therapeutic effect against gastrointestinal cancers.
Results indicated improved management of gastric cancer in experimental models.
Abstract
Our in vitro and in vivo results demonstrated that exoshells possessed significant potential as an orally administered, titratable therapeutic platform for the management of gastrointestinal cancers.
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Bioorthogonal catalytic centres engineered for gastrointestinal stabilization provide oral delivery for the treatment of gastric cancer | Synapse