Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats | Synapse
March 3, 2026
Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats
Key Points
Impairment of spatial learning and memory occurs due to chronic melamine cyanurate exposure in adolescent rats, affecting their cognitive abilities.
Key evidence indicates that oxidative stress and altered autophagy pathways significantly disrupt synaptic plasticity in the hippocampus of exposed rats.
Assessment using established behavioral tests shows deteriorated cognitive performance correlating with melamine cyanurate exposure duration and intensity.
Findings highlight critical neurotoxic mechanisms, with implications for understanding cognitive deficits resulting from environmental contaminant exposure.